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Gregory S. Hageman, PhD
- Specialty: Ophthalmic cellular and molecular biology
- Iowa Entrepreneurial Endowed Professor
Professor of Ophthalmology
- Campus Address
- 11190E PFP
- Education
- BA (Biological Sciences), University of Southern California
- PhD (Biology), University of Southern California
- Certification
- DEA Registration
- Missouri BNDD Registration
- Professional Affiliations
- American Society for Cell Biology
- Association for Research in Vision and Ophthalmology
- Electron Microscopy Society of America
- Central States Electron Microscopy Society
- International Brain Research Organization
- International Society for Eye Research
- Society for Neuroscience
- Vitreous Society
- Research Interest and Current Projects
- Cellular and molecular mechanisms involved in the etiology of
age-related macular degeneration: emphasis on characterization of
ocular drusen, basal laminar deposits, and Bruch's membrane; determination
of the role of immunomodulatory processes; analyses of abnormal
serum proteins and autoantibodies; identification of "candidate"
proteins and genes; mutational analysis of candidate genes; assessment
of differential gene expression; and characterization of systemic
disease correlations.
- Correlation between macular degeneration and other systemic diseases,
including abdominal aortic aneurysm.
- Biochemical, structural and molecular characterization of the
primate fovea and macula, including the RPE-Bruch¹s membrane
interface, and identification of macula-associated genes.
- Ocular gene discovery: generation of a comprehensive collection
of cDNAs representing most RNAs expressed in the human eye, at different
stages of development, in both normal and diseased tissues.
- Structural, compositional, and functional analyses of primate
cone photoreceptors and associated interphotoreceptor matrix domains:
emphasis on the role of the IPM in retinal adhesion and photoreceptor
cell viability; disease-associated compositional changes: and mutation
screening in macular dystrophies.
see profile of Dr. Hageman in the Fall 2006 Medicine Iowa: The UI Carver College of Medicine quarterly alumni magazine
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