|
|
Gregory S. Hageman, PhD
- Specialty: Ophthalmic cellular and molecular biology
- Iowa Entrepreneurial Endowed Professor
Professor of Ophthalmology & Visual Sciences
- Campus Address
- 11190E PFP
- Other Academic, Foundation, and Corporate Affiliations
- Associate Faculty, University of California Santa Barbara Center for the Study of Macular Degeneration
- Chief Scientific Officer, Optherion, Inc.
- Honorary Professor, Shandong Eye Institute & Hospital, Qingdao, People's Republic of China
- Honorary Professor, Queens University, Belfast, Northern Ireland
- Education
- BA (Biological Sciences), University of Southern California
- PhD (Biology), University of Southern California
- Certification
- DEA Registration
- Missouri BNDD Registration
- Professional Affiliations
- Macula Society
- American Society for Cell Biology
- Association for Research in Vision and Ophthalmology
- Electron Microscopy Society of America
- Central States Electron Microscopy Society
- International Brain Research Organization
- International Society for Eye Research
- Society for Neuroscience
- Vitreous Society
- Research Interest and Current Projects
- Cellular and molecular mechanisms involved in the etiology of
age-related macular degeneration: emphasis on ccomplement genetics; relationship between AMD and variations in genes encoding other complement-, and inflammation-, and drusen-related molecules; clinicopathologic correlations; delineation of the association between complement gene variations and other complement- and inflammation-associated diseases; characterization of ocular drusen, basal laminar deposits, and Bruch's membrane; determination
of the role of immunomodulatory processes; analyses of abnormal
serum proteins and autoantibodies; identification of molecules responsible for triggering the alternative complement pathway at the RPE/choroid interface; identification of "candidate" proteins and genes; mutational analysis of candidate genes; assessment
of differential gene expression; and characterization of systemic
disease correlations.
- Correlation between macular degeneration and other systemic diseases.
- Biochemical, structural and molecular characterization of the
primate fovea and macula, including the RPE-Bruch¹s membrane
interface, and identification of macula-associated genes.
- Ocular gene discovery: generation of a comprehensive collection
of cDNAs representing most RNAs expressed in the human eye, at different
stages of development, in both normal and diseased tissues.
- Structural, compositional, and functional analyses of primate
cone photoreceptors and associated interphotoreceptor matrix domains:
emphasis on the role of the IPM in retinal adhesion and photoreceptor
cell viability; disease-associated compositional changes: and mutation
screening in macular dystrophies.
see profile of Dr. Hageman in the Fall 2006 Medicine Iowa: The UI Carver College of Medicine quarterly alumni magazine
|
click on image for larger picture
|
|
