University of Iowa Health Care

Ophthalmology and Visual Sciences

EyeRounds.org

Pseudoxanthoma elasticum

Contributor: Jesse Vislisel, MD

Photographer: Brice Critser, CRA

Pseudoxanthoma elasticum

(see higher resolution of right eye, left eye)

Pseudoxanthoma elasicum (PXE, Gronblad-Strandberg syndrome) is due to a mutation in the ABCC6 gene and most commonly follows an autosomal recessive inheritance pattern. It is the most common cause of angioid streaks, or breaks in a thickened and calcified Bruch membrane, visible as dark red-brown bands radiating from the optic discs in these photos. Note the stippled, peau d'orange appearance of the fundi which is typical for this disorder.


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Ophthalmic Atlas Images by EyeRounds.org, The University of Iowa are licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.

last updated: 8/20/2013
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