University of Iowa Health Care

Ophthalmology and Visual Sciences

EyeRounds.org

Schnyder Corneal Dystrophy

Contributor: Jesse Vislisel, MD

Photographer:  Tracy Aly, CRA

Schnyder crystalline corneal dystrophy is an autosomal dominant condition caused by a mutation in the UbiA prenyltransferase domain-containing protein 1 (UVIAD1).  It results in deposition of cholesterol and phospholipid crystals in the central corneal stroma.  Later, the patients develop a dense corneal arcus, and eventually midperipheral corneal opacification and decreased corneal sensation.

OMIM #121800 


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last updated: 03/02/2015