• Disease modeling: Using iPSCs to model retinal disease and identify the role of a new disease causing gene in the pathophysiology of RP.
• Dr.Tucker and co-investigator John Fingert awarded a National Glaucoma Research grant of $100,000 for their research project: Stem Cell Approaches to Glaucoma from BrightFocus (Formerly American Health Assistance Foundation).
Adult Mouse iPSCs
Retinal progenitor cells break through the glial scar and integrate
within the host dystrophic retina post-transplantation
The intact laminar structure of a photoreceptor sheet makes it an
attractive tissue for ocular transplantation
Teratomas contain tissues of all 3 germ layers including vascular tubes
Formation of a large teratoma at 4 weeks post injection of
undifferentiated iPSCs into a mouse eye
Retinal degeneration stimulates muller cell activity and glial scar formation at the outer
limits of the diseased retina
iPSCs generated from adult mice expressing the red fluorescent reporter dsRed
Mitotically active fibroblast cell being reprogramed
Bipolar cells making connections with newly engrafted iPSCs