Research News
• Disease modeling: Using iPSCs to model retinal disease and identify the role of a new disease causing gene in the pathophysiology of RP.
• Dr.Tucker and co-investigator John Fingert awarded a National Glaucoma Research grant of $100,000 for their research project: Stem Cell Approaches to Glaucoma from BrightFocus (Formerly American Health Assistance Foundation).
Program in Stem Cell Biology
Medical Education and Biomedical Research Facility
Tucker Laboratory Research
-
RPC Transplantation
-
Photoreceptor Sheets
-
Teratoma Characterization
-
Teratoma Formation
-
Retinal Gliosis
-
Adult Mouse iPSCs
-
iPSC Generation
-
Retinal Transplantation
RPC Transplantation
Retinal progenitor cells break through the glial scar and integrate
within the host dystrophic retina post-transplantation
Photoreceptor Sheets
The intact laminar structure of a photoreceptor sheet makes it an
attractive tissue for ocular transplantation
Teratoma Characterization
Teratomas contain tissues of all 3 germ layers including vascular tubes
Teratoma Formation
Formation of a large teratoma at 4 weeks post injection of
undifferentiated iPSCs into a mouse eye
Retinal Gliosis
Retinal degeneration stimulates muller cell activity and glial scar formation at the outer
limits of the diseased retina
Adult Mouse iPSCs
iPSCs generated from adult mice expressing the red fluorescent reporter dsRed
iPSC Generation
Mitotically active fibroblast cell being reprogramed
Retinal Transplantation
Bipolar cells making connections with newly engrafted iPSCs
|
Copyright © 2011 The University of Iowa, All Rights Reserved |
