Anterior subcapsular cataracts (ASC) form after anterior lens epithelial cells become necrotic from a variety of causes including iritis, keratitis, inflammation associated with atopic dermatitis, irradiation, or electrical burns. The opacification of the lens is due to a migration of adjacent epithelial cells into the damaged area and subsequent transformation of these cells into a plaque of multiple layers of myofibroblasts. The most posterior layer of these cells remain epithelial cells and will produce a new lens capsule. Over time the myofibroblasts resolve leaving a wrinkled appearance to the lens capsule. A duplication cataract occurs when a cortical cataract develops in the same area as the ASC.
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