University of Iowa Health Care

Ophthalmology and Visual Sciences

EyeRounds Online Atlas of Ophthalmology

Contributor: Andrew Doan, MD, PhD, University of Iowa

Updated and Expanded by: Cameron Wagner, BS  and Lorraine M. Provencher, MD

Pseudoexfoliation glaucoma

Pseudoexfoliation syndrome (PXF) is an age-related disease characterized by an accumulation of grey and white fibrillar extracellular material in ocular tissues. The extracellular material is thought to be produced by lens capsule, ciliary body, corneal endothelium, zonules, and the iris. PXF is one of the most common causes of secondary open angle glaucoma, i.e. pseudoexfoliation glaucoma (PXG). Aggregation of extracellular material can cause congestion of the trabecular meshwork, leading to an increase in intraocular pressure. Patients affected by PXG may have a poor response to medical treatment and may go on to require laser or surgical therapy.


  1. Plateroti P, Plateroti AM, Abdolrahimzadeh S, Scuderi G. 2015. Pseudoexfoliation syndrome and pseudoexfoliation glaucoma: a review of literature with updates and surgical management. Journal of Ophthalmology. 2015:1-9.

pseudoexfoliation glaucoma

1) pseudoexfoliation material on pupil margin

pseudoexfoliation glaucoma

2) bullseye lesion on lens capsule

pseudoexfoliation glaucoma

3) Sampaolesi's line on gonioscopy

pseudoexfoliation glaucoma 4) pseudoexfoliation material on lens zonules (causes zonular weakness)

see Case 8

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last updated: 03/24/2017; originally posted: 02-08-2008
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