This site uses tracking information. Visit our privacy policy. Click to agree to this policy and not see this again.

Ophthalmology and Visual Sciences

Pseudoexfoliation glaucoma

Pseudoexfoliation glaucoma

Category(ies): Glaucoma, Iris
Contributor: Andrew Doan, MD, PhD
Updated and Expanded by:: Cameron Wagner, BS and Lorraine M. Provencher, MD

Pseudoexfoliation syndrome (PXF) is an age-related disease characterized by an accumulation of grey and white fibrillar extracellular material in ocular tissues. The extracellular material is thought to be produced by lens capsule, ciliary body, corneal endothelium, zonules, and the iris. PXF is one of the most common causes of secondary open angle glaucoma, i.e. pseudoexfoliation glaucoma (PXG). Aggregation of extracellular material can cause congestion of the trabecular meshwork, leading to an increase in intraocular pressure. Patients affected by PXG may have a poor response to medical treatment and may go on to require laser or surgical therapy.

pseudoexfoliation material on pupil margin
1) pseudoexfoliation material on pupil margin
bullseye lesion on lens capsule
2) bullseye lesion on lens capsule
 Sampaolesi's line on gonioscopy
3) Sampaolesi's line on gonioscopy
pseudoexfoliation material on lens zonules
4) pseudoexfoliation material on lens zonules (causes zonular weakness)
  • Plateroti P, Plateroti AM, Abdolrahimzadeh S, Scuderi G. 2015. Pseudoexfoliation syndrome and pseudoexfoliation glaucoma: a review of literature with updates and surgical management. Journal of Ophthalmology. 2015:1-9.

Image Permissions:
Creative Commons

Ophthalmic Atlas Images by, The University of Iowa are licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.