Sorsby macular dystrophy
Contributor: Jesse Vislisel, MD
Photographer: Stefani Karakas, CRA
Sorsby macular dystrophy is an autosomal dominant condition caused by a mutation in the TIMP3 gene. Patients with this condition typically maintain normal acuity until their 40's when they develop severe, bilateral choroidal neovascular membranes. The macular lesions later have a "pseudo-inflammatory" appearance with geographic atrophy and dense clumps of black pigmentation, as seen in these photographs.
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Ophthalmic Atlas Images by EyeRounds.org, The University of Iowa are licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.